Case Study | 7 minutes
Sjögren’s disease is not always straightforward. Some patients present with severe dry eyes and dry mouth, yet standard serological tests are negative and salivary gland biopsy findings appear normal.
In this short, case-based course, you’ll follow Maria’s diagnostic journey and explore the concept of functional autoimmunity in Sjögren’s disease. Drawing on insights from Prof. Torsten Witte’s International Friday Meeting presentation, the course examines how muscarinic receptor antibodies, particularly anti-M3 antibodies, may contribute to symptoms even when traditional diagnostic markers are absent.
Learning outcomes
By completing this course, you will be able to:
- Recognize the limitations of conventional Sjögren’s diagnostic tests.
- Explain how functional autoimmunity can contribute to sicca symptoms.
- Apply these concepts to a clinical case.