The Mosaic of Autoimmunity Newsletter

August is Autoinflammatory Awareness Month, a reminder that inflammation doesn't always start where you'd expect. From a single mutated gene to a ruptured implant to a long-haul flight, this issue traces it back to the source.

🧬  IT STARTS IN THE GENES

In PS05, Dr. Woo-Joong Kim's case links a new PRKCD mutation to disabling inflammation, proof that one altered gene copy can cause real disease. In PS24, Prof. Jan Willem Cohen Tervaert makes the case for cathepsin C as a steroid-sparing target in vasculitis.

Two sessions, one takeaway: rare-disease genetics keep reshaping how we treat inflammation.

🦠  IT STARTS IN THE GUT

A new hypothesis proposes that our microbiome, inherited at birth, may quietly shape autoimmunity, brain health, and metabolic disease.

✈  IT STARTS WITH A BOARDING PASS

Jet lag isn't just fatigue. Prof. Maurizio Cutolo shows how circadian disruption from travel can influence RA activity, in a 5-minute, case-based course.

💉  IT STARTS WITH AN IMPLANT, OR SOMEWHERE YOU'D NEVER THINK TO LOOK

Join us live for International Friday Meeting No. 205 on September 4, 4:00 PM CET, seven talks on inflammation's more unexpected triggers, from breast implants and ASIA syndrome to incidental ANA positivity, fibromyalgia, thyroid drug risk, lupus senescence, and pregnancy loss in APS.

Save your spot, because inflammation doesn't always begin where you'd expect.