AD/PD™ Journal Club: The Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer’s Disease

Mark your calendars for the first of 2025 AD/PD™ Journal Club, where we’ll be discussing “The Inflammation-Induced Dysregulation of Reelin Homeostasis Hypothesis of Alzheimer’s Disease”.

This initiative is made possible thanks to the help of the Journal of Alzheimer’s Disease.

The author’s papers will be available free of access to all journal attendees here.

Agenda:

  1. Welcome: Prof. Lockhart will introduce Dr. Reive and Dr. Caruncho.
  2. Presentation: Dr. Reive will introduce the latest publication and the implications in the field of the description of AD risk in disorders involving Reelin dysregulation and inflammation.
  3. Discussion: Q&A with the speakers, moderated by Prof. Lockhart.

Faculty

Moderator

Samuel N. Lockhart
Senior Scientific Director (Perceptive), Adjunct Associate Professor (Wake Forest), Perceptive/Wake Forest School of Medicine

Dr. Samuel Lockhart is a Neuroscientist with 15+ years’ experience investigating late-life brain health using imaging, cognitive, and biomarker data, aiming to develop interventions for preventing disease and decline. Having worked with multiple NIH Alzheimer’s Disease Research Centers (ADRCs), Dr. Lockhart has over 80 publications on aging and neurodegenerative disease, was founding Co-Leader of the Wake Forest ADRC Imaging Biomarker Core, and led brain imaging ancillaries to clinical trials impacting brain health. Sam continues to provide industry scientific leadership in the design and implementation of imaging biomarker solutions in clinical trials.

Speakers

Brady Reive
PhD Neuroscience, University of Victoria

Dr. Brady Reive is a Canadian with a PhD in Neuroscience from the University of Victoria with a background in behavioral neuroscience, major depression and Reelin.

Hector J. Caruncho
University of Victoria

Neuropharmacologist with a background in comparative neuroanatomy. From fish neurobiology (my PhD thesis) I moved to study the neuropharmacology of GABAA receptors and GABAergic systems in animal models of neuromotor disorders. For the past 25 years I have been working on Reelin and mental disorders, and in the past decade on biomarkers of psychiatric and neurologic disorders. I am also fostering patient-oriented research and work in the community with several NGOs focusing on mental health.

Love reading, traveling, and sports. My family (including my dog, of course) is my sanctuary.

This initiative is made possible thanks to the help of the Journal of Alzheimer’s Disease.