Mark your calendars for the first ever joint
AD/PD™ and The Mosaic of Autoimmunity webinar – “Crossing Boundaries: Exploring Polyamine Dysregulation in Alzheimer’s and Autoimmune Disorders”!
This webinar provides a unique interdisciplinary platform for Health Care Practitioners and researchers specializing in autoimmunity and neurodegenerative diseases to explore the emerging connections between Alzheimer’s disease and autoimmune processes.
Date: 25 February 2025
Time: 16:30 CET
Seats are limited
Objectives:
- Examine the molecular mechanisms underlying polyamine metabolism and its implications for Alzheimer’s disease as presented in the article “Polyamine Dysregulation and Nucleolar Disruption in Alzheimer’s Disease“.
- Analyze the potential links between autoimmune processes and neurodegenerative disorders, with a focus on Alzheimer’s disease.
- Assess how targeting nucleolar dynamics and polyamine metabolism could serve as novel therapeutic strategies for Alzheimer’s disease and related disorders.
- Foster interdisciplinary dialogue between specialists in autoimmunity and neurodegeneration to broaden understanding of the molecular mechanisms and clinical implications discussed in the webinar.
Agenda:
- Welcome: Dr. Ruitenberg will introduce speakers and agenda (5 min)
- First Presentation: “Autoimmune Theories & Links to Neurodegeneration“ (30min)
• Lupus theory: “X chromosome-nucleolus nexus” hypothesis
• Alzheimer’s hypothesis: Polyamines and nucleolar dynamics
• Speculative ideas: Alu elements and abnormal protein modifications in autoimmune diseases
• Experimental approaches: Brain organoids vs. mouse models - Poll Questions (10-15 min)
- Second Presentation: “Alzheimer’s Disease Perspectives” (15 min)
• Complementary/alternative views on nucleolar dysfunction
• Polyamine imbalances and neurodegeneration
• Therapeutic and translational insights - Discussion: Q&A session with the speakers and audience questions (25 min)
Faculty
Moderator
Merit Ruitenberg
Leiden University, the Netherlands
Speakers
Marina Jendrach
Privatdozen, Charité Universitätsklinik Berlin
2017 Granting of the title „Privatdozentin for
Experimental Neuropathology” at the Charité Berlin
2014 – today Scientist at the department of Neuropathology, Charité, Berlin
2010 – 2014 scientist in the Group for Experimental Neurology, University Hospital Frankfurt/Main
2010 Inaugural lecture and granting of the title „Privatdozentin for Cell Biology” at the Goethe University Frankfurt/Main
Professorial dissertation (Habilitationsschrift): „The role of mitochondria in the aging process and age-progressive
diseases“
2002 – 2010 Postdoc at the Kinematic Cell Research Group, Goethe University Frankfurt/Main
1998 – 2002 Postdoc at the department for Clinical Pharmacology,
University of Ulm
1994 –1998: PhD studies at the Institute for Virology and Immunology at the University Würzburg. PhD thesis: “Internal ribosomal entry in a bicistronic Coronavirus mRNA“
1986 – 1993: Diploma in Mikrobiology, Christian-Albrechts-University of Kiel, Germany
Wesley Brooks
Courtesy Assistant Professor, (University of South Florida, Chemistry), Associate Editor, (Journal of Translational Autoimmunity)
Dr. Brooks worked in business IT for 13 years (Baxter and Kimberly-Clark), but decided to change careers to study epigenetics in autoimmunity. He obtained a PhD (Medical College of Wisconsin) studying histone and DNA interactions, then studied X chromosome inactivation as an NIH post-doc fellow (University of Florida), followed by work in computational drug discovery (University of South Florida) including targeting polyamine enzymes and development of autoimmune-related hypotheses. Dr. Brooks has been an invited speaker internationally including Zurich, Brest, Kazan, and other sites.
Seats are limited